{"product_id":"current-topics-in-microbiology-and-immunology-ergebnisse-der-mikrobiologie-und-immunitatsforschung-volume-70-paperback-2","title":"Current Topics in Microbiology and Immunology \/ Ergebnisse Der Mikrobiologie Und Immunitätsforschung: Volume 70 - Paperback","description":"\u003cdiv\u003e\u003cp style=\"text-align: right;\"\u003e\u003ca href=\"https:\/\/reportcopyrightinfringement.com\/\" target=\"_blank\" rel=\"nofollow\"\u003e\u003cb\u003eReport copyright infringement\u003c\/b\u003e\u003c\/a\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cp\u003eby \u003cb\u003eW. Arber\u003c\/b\u003e (Author), \u003cb\u003eW. Henle\u003c\/b\u003e (Author), \u003cb\u003eP. H. Hofschneider\u003c\/b\u003e (Author)\u003c\/p\u003e\u003cp\u003eThe processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus group necessitates a description, albeit brief, of the properties of the group and, most importantly, of their genetic material. The herpesviruses comprise a group of relatively large (100-150 nm), enveloped viruses. The envelope surrounds an icosahedral capsid enclosing a core which contains double- stranded DNA (ROIZMAN, 1969). The group is thus defined on the basis of a common virion morphology. In addition to a common structure, members of the group share a number of biological properties such as a similar replicative cycle, the ability to cause latent and chronic infections, and the ability to induce antigenic modifications of infected cell membranes. Several herpes- viruses have been associated recently with malignancies in man and animals (KLEIN, 1972). Herpesviruses are ubiquitous and have been described in over 30 different species (HUNT and MELENDEZ, 1969; WILDY, 1971; FARLEY et aI., 1972; KAZAMA and SCHORNSTEIN, 1972; NAHMIAS et aI., 1972; ROlZMAN et aI., 1973). Their widespread occurrence in nature suggests a common ancestor.\u003c\/p\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 136\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.31 x 9.61 x 6.69 IN\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e November 11, 2011\u003c\/div\u003e\n            ","brand":"BooksCloud","offers":[{"title":"Default Title","offer_id":48339268731101,"sku":"9783642661037","price":106.9,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0811\/9867\/8237\/files\/WKV61BabQ19783642661037_b2fd9ab0-c88a-4358-81cf-0530a685c948.webp?v=1786031042","url":"https:\/\/handfulofbooks.com\/products\/current-topics-in-microbiology-and-immunology-ergebnisse-der-mikrobiologie-und-immunitatsforschung-volume-70-paperback-2","provider":"Handful of Books","version":"1.0","type":"link"}